TRY AND TRY AGAIN...UNTILL YOU SUCCEED

''it ain't about how hard you hit. It's about how hard you can get hit and keep moving forward. How much you can take and keep moving forward. That's how winning is done!''







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so please discuss the doubts you have...





HAPPY STUDYING !!!





regards



DR KUNAL MAHAJAN



mbbs(rpgmc tanda)

md med student(pgims rohtak)









Thursday, April 1, 2010

MONOCLONAL ANTIBODIES to remember

1)RITUXIMAB--------ANTI CD20 used in ANCA associated vasculitis,,B cell lymphomas,,rheumatoid arthtitis,,SLE,,ITP,,TTP,,pemphigus vulgaris (PGI QUES)

2)TRASTUZUMAB-----ANTI HER-2/NEU RECEPTOR used in breast cancer [AIIMS 08]

3)ALEMTUZUMAB------ANTI CD52 [AIIMSMCQ] used in chronic lymphoid leukemia and T-cell cancers

4)BEVACIZUMAB-------ANTI VEGF used in CA colon,breast.lung...also tried in ca.ovary

5)CITUXIMAB-------ANTI EGFR used in colorectal cancer refratory to chemotherapy and in primary treatment of head and neck cancers[AI 2009]

6)PANITUMOMAB------ANTI EGFR uses same as cituximab

7)OMALIZUMAB------ANTI IgE (MCQ) used in bronchial asthma

8)ECULIZUMAB--------ANTI COMPLEMENT PROTEIN C5-------used in PNH(paroxysmal nocturnal haemoglobinuria)

9)NATALIZUMAB------ANTI INTEGRIN---------------used in MULTIPLE SCLEROSIS

10)ALEFACEPT--------ANTI CD2--------------used in psoriasis

11)EFALIZUMAB------ANTI CD11a---------used in psoriasis

12)GEMTUZUMAB---ANTI CD33----------used in AML

13)PALIVIZUMAB----------used in RSV PNEUMONIA (PGI QUES)

14)DONESUMAB--------ANTI RANK LIGAND------used in osteoporosis

15)MUROMONAB(OKT-3) ------ANTI CD3------used in renal transplant rejection
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