TRY AND TRY AGAIN...UNTILL YOU SUCCEED

''it ain't about how hard you hit. It's about how hard you can get hit and keep moving forward. How much you can take and keep moving forward. That's how winning is done!''







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regards



DR KUNAL MAHAJAN



mbbs(rpgmc tanda)

md med student(pgims rohtak)









Friday, April 2, 2010

prion disease

PRION DISEASE==FEW IMPORTANT FACTS TO REMEMBER =ALL MCQs in recent allindia/aiims


1)prion disease may manifest as SPORADIC/INFECTIOUS/GENETIC disease
2)most common prion disease in human =SPORADIC CREUTZFELDT JAKOB DISEASE
3)prions are INFECTIOUS PROTEINACEOUS PARTICLES devoid of nucleic acids
4)prions cause misfolding of other proteins
5)normal cellular isoform of prion protein is PRPc (with alpha helix as its secondary structure)
infectious isoform is PRPsc (with beta sheets as its secondary structure)
it is this ''transition from alpha helix to beta sheets secondary structure'' that is responsible for its pathogenesis.
6)gene for prion protein is located on short arm of chromosome 20
7)prions are most resistant infectious particles to antiseptics
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